MULTIDES

INTERREG4A-2seas PROJECT "MULTIDES"
Development of a multifunctional drug eluting stent


MULTIDES website

The MultiDES project was funded by the INTERREG IV A 2seas programme which was carrying out research on the development of a new multifunctional DES. We aimed to apply a biocompatible and hemocompatible layer on the stent surface mainly through a jet coating and/or a grafting or cross-linking process.

The process involved the following steps:

· a) The stent strut is coated with a biocompatible and biodegradable polymer loaded with an antiproliferative active substance(s) aiming to reduce restenosis.

· b) A second coating of the stent with a biocompatible and hemocompatible polymer which acts as cage molecule to release an anti-platelet active agent to prevent early stage thrombosis.

· c) An optional top-coating layer free of drug(s) to further control the release rates of the combined active substances.

At present the existence of a marketed DES loaded with two different active molecules has not been developed due to the lack of appropriate technology. In this case the selected polymers can provide a breakthrough carrier system by loading simultaneously at least two different drugs that could act synergistically. The heterogeneous coating of stent struts will provide different drug loadings and release profiles due to the physicochemical properties of each drug molecule. The applied coating technology provides accurate, reproducible, scalable coating with negligible drug loss.

The coated polymeric materials used for development of the MultiDES have now been fully evaluated in terms of cytotoxicity, biocompatibility and hemocompatibility. The in vitro results showed excellent performance suggesting that polymers are safe to be used for stent coating.



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